Question

Inhibition of p-glycoprotein by a drug such as quinidine may lead to

Answer 1

P-glycoprotein is an energy-dependent efflux transporter. Simply stated, Pgp pumps drug molecules out of cells. Thus, when quinidine is coadministered with digoxin, quinidine inhibition of P-gp results in an increase in digoxin absorption and a reduction of digoxin elimination, primarily via the kidney.

Answer 2

Answer:

P-glycoprotein is an energy-dependent efflux transporter. Simply stated, Pgp pumps drug molecules out of cells