insulin can not enter into the cell membrane explain it
Answers
Answer:
Molecules that practice simple diffusion must be small and nonpolar*, in order to pass through the membrane. ... Insulin triggers GLUT4 to insert into the membranes of these cells so that glucose can be taken in from the blood.
Answer:
Insulin can be covalently attached to a large polymers of Sepharose through the α-amino group of the N-terminal residue of the B chain, or through the ε-amino group of its lysyl residue. Such derivatives effectively increase the utilization of glucose, and suppress the hormone-stimulated lipolysis, of isolated fat cells. The effects occur with concentrations of insulin-Sepharose that are nearly as low as those of native insulin, and the maximal responses are the same. The results indicate that interaction of insulin with superficial membrane structures alone may suffice to initiate transport as well as other metabolic alterations.