Insulin secretion with respect to carbohydrate ingestion
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pancreas is known as a dual gland
because endocrine system - insulin
exocrine system - digestive juices
Factors responsible for spontaneoushypoglycaemia were investigated in 23 gastrectomy patients and two patients with vagotomy and pyloroplasty. Plasma insulin and capillary blood glucose levels were followed aftergiving 175mlof 50%glucose orally.Ingastrecto patients a significant correlation was foundbetweentheheightofthepeakbloodglucoseandinsulinlevelsfor thesame individual.Patientswithhighpeakglucoseandinsulinlevelswere significantlymore likelytodevelophypoglycaemialaterinthetest.Thesefindingsare compatiblewiththesuggestion thatthemajorfactorpredisposingtohypoglycaemiaisa fasterthanaverage rateofemptyingofthe gastricremnant,butthisdoesnotexplainaltheresults.Intwocases, hypoglycaemiafollowedan abnormallylargeinsulinresponse tooralglucose.Theresultsofinsulininjectiontestsin14patients donotexcludethefurtherpossibilitythatinsome cases hypoglycaemiaisduetoexcessiveinsulin sensitivity.
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