Question

Inter fungal and fungal bacterial intraction

Answer 1

Microbiome profiles can be used to explore co-occurrence and co-exclusion patterns in oral communities. Associations inferred from this analysis could be used to generate hypotheses regarding synergistic or antagonistic interactions among fungi and bacteria. Several approaches to this analysis have been proposed. Duran-Pinedo et al.  used weighted correlation network analysis to identify associations between bacterial species in subgingival plaque. In a proof of principle experiment, these authors demonstrated that correlation network information could improve the growth of uncultivated taxa in laboratory media. Several Prevotella spp. were identified as candidate growth partners for the uncultivated Tannerella sp. HOT286, based on direct associations in microbial network modules. Using the helper Prevotella spp. in a co-cultivation approach, the authors were able to enrich for Tannerella sp in solid laboratory media.
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