Intracytoplasmic accumulation of immunoglobulins in plasma cells
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Intracytoplasmic inclusions in PCs were first described by Russel in 1890 and subsequently termed Russell bodies which are accumulations of mucopolysaccharides and immunoglobulins within the rough endoplasmic reticulum. found that these inclusions are exclusively seen in MM with kappa light chain type paraprotein.
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Immunoglobulins, also known as antibodies, are glycoprotein molecules produced by plasma cells (white blood cells). They act as a critical part of the immune response by specifically recognizing and binding to particular antigens, such as bacteria or viruses, and aiding in their destruction.
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