Question

Is CD44 degraded in lysosome together with hyaluronan after CD44 mediated endocytosis of hyaluronic acid?

no spam ❌ :-\:-\​

Answer 1

The CD44 antigen is a glycoprotein involved in cell–cell interactions, cell adhesion and migration. CD44 has been referred to as HCAM (homing cell adhesion molecule), Pgp-1 (phagocytic glycoprotein-1), Hermes antigen, lymphocyte homing receptor, ECM-III, and HUTCH-1.

All glycoproteins entering the lysosome should be degraded by the drop in pH and one of the 50 to 60 ies acid hydrolases.

Answer 2

Also when RHAMM binds hyaluronic acid, they get internalized, will RHAMM also be degraded?

Or both CD44 and RHAMM will be transferred back to the cell membrane?

Asking for breast cancer cell line MDA-MB-231 and mesenchymal stem cell line C3H10T1/2.

Ok

Your intro