Question

Is it possible to see adult female hemophiliacs ? Whatever maybe your answer, please justify . An explanation with Punnet Square will be appreciated.​

Answer 1

$\underline{\underline{\sf{\maltese\:\:Question}}}$

• Is it possible to see adult female hemophiliacs ?

$\underline{\underline{\sf{\maltese\:\:Introduction}}}$

Inheritance is the process of transmitting the traits from parent to offspring. Traits of an organism are controlled by genes (small segment on DNA) which have two or more contrasting pairs known as allele.

$\underline{\underline{\sf{\maltese\:\:Answer}}}$

• Adult Female hemophiliacs can't be seen because they don't live till puberty

$\underline{\underline{\sf{\maltese\:\:Explanation}}}$

Alleles controlling a trait can be dominant or recessive. A dominant allele is expressed in both homozygous (pair of alleles is identical on both the homologous chromosomes) and heterozygous (pair of alleles are contrasting on the two homologous chromosomes) conditions. A recessive allele can only express in the case of homozygous condition.   X-linked traits are controlled by X-chromosome (sex chromosome) and therefore sex of an individual has role in pattern of inheritance of such traits. Females are homozygous for X chromosome and thus there is less probability of females getting affected with X-linked recessive alleles but they can be carrier and can transfer the trait to their offspring. Males are hemizygous for X-chromosome and thus there is equal probability of them being affected with either X-linked dominant or recessive alleles.  Male offspring inherit X-chromosome from mother so they inherit X-linked disease gene from mother only while females can inherit X-linked disease gene from both the parents. Hemophilia is an X-linked inherited disorder that is inherited in a recessive manner. The ability to form blood clots is impaired in the affected individuals. This leads to problems in stopping blood loss from any injured site or a natural process like menstruation in humans.

$\underline{\underline{\sf{\maltese\:\:Different\:cases\: possible\: in \: hemophilia\: inheritance}}}$

Case 1 - Refer to Attachment 1

Cross Between Partner's Parents

$\begin{tabular}{|c|c|c|} \cline{1-3} & \sf{X} & \sf{X} \\ \cline{1-3} X^\sf{h} & XX^\sf{h} & XX^\sf{h} \\ \cline{1-3} \sf{Y} & \sf{XY} & \sf{XY} \\ \cline{1-3} \end{tabular}$

• Therefore, all the females will be carrier and no male affected.

Case 2 - Refer to Attachment 2

Cross Between Partner's Parents

$\begin{tabular}{|c|c|c|} \cline{1-3} & X^\sf{h} & \sf{X} \\ \cline{1-3} X^\sf{h} & X^{\sf{h}}X^{\sf{h}}\:\sf{cannot\:survive} & XX^\sf{h} \\ \cline{1-3} \sf{Y} & X^{\sf{h}}\sf{Y} & \sf{XY} \\ \cline{1-3} \end{tabular}$

• Therefore, one female will be carrier, One male will be affected while one male will be normal.

Case 3 - Refer to Attachment 3

Cross Between Partner's Parents

$\begin{tabular}{|c|c|c|} \cline{1-3} & X^\sf{h} & \sf{X} \\ \cline{1-3} X & XX^\sf{h} & \sf{XX} \\ \cline{1-3} \sf{Y} & X^{\sf{h}}\sf{Y} & \sf{XY} \\ \cline{1-3} \end{tabular}$

• Therefore, one female will be carrier, one will be normal one male will be affected while one will be normal

$\underline{\underline{\sf{\maltese\:\:Note}}}$

• There will be no case of females affected because affected females cannot survive for long to give birth.

Answer 2

$\huge{\colorbox{pink}{ Answer }}$

Step 1

Inheritance is the process of transmitting the traits from parent to offspring. Traits of an organism are controlled by genes (small segment on DNA) which have two or more contrasting pairs known as allele.

Step 2

Alleles controlling a trait can be dominant or recessive. A dominant allele is expressed in both homozygous (pair of alleles is identical on both the homologous chromosomes) and heterozygous (pair of alleles are contrasting on the two homologous chromosomes) conditions. A recessive allele can only express in the case of homozygous condition.

Alleles controlling a trait can be dominant or recessive. A dominant allele is expressed in both homozygous (pair of alleles is identical on both the homologous chromosomes) and heterozygous (pair of alleles are contrasting on the two homologous chromosomes) conditions. A recessive allele can only express in the case of homozygous condition.X-linked traits are controlled by X-chromosome (sex chromosome) and therefore sex of an individual has role in pattern of inheritance of such traits. Females are homozygous for X chromosome and thus there is less probability of females getting affected with X-linked recessive alleles but they can be carrier and can transfer the trait to their offspring. Males are hemizygous for X-chromosome and thus there is equal probability of them being affected with either X-linked dominant or recessive alleles.

Alleles controlling a trait can be dominant or recessive. A dominant allele is expressed in both homozygous (pair of alleles is identical on both the homologous chromosomes) and heterozygous (pair of alleles are contrasting on the two homologous chromosomes) conditions. A recessive allele can only express in the case of homozygous condition.X-linked traits are controlled by X-chromosome (sex chromosome) and therefore sex of an individual has role in pattern of inheritance of such traits. Females are homozygous for X chromosome and thus there is less probability of females getting affected with X-linked recessive alleles but they can be carrier and can transfer the trait to their offspring. Males are hemizygous for X-chromosome and thus there is equal probability of them being affected with either X-linked dominant or recessive alleles.Male offspring inherit X-chromosome from mother so they inherit X-linked disease gene from mother only while females can inherit X-linked disease gene from both the parents.

Step 3

Hemophilia is an X-linked inherited disorder that is inherited in a recessive manner. The ability to form blood clots is impaired in the affected individuals. This leads to problems in stopping blood loss from any injured site or a natural process like menstruation in humans.

Hemophilia is an X-linked inherited disorder that is inherited in a recessive manner. The ability to form blood clots is impaired in the affected individuals. This leads to problems in stopping blood loss from any injured site or a natural process like menstruation in humans.Men are commonly affected as compared to females. Females can be carriers of the disease but severely affected females cannot survive for lo...

${\boxed{Hope \: it \: helps \: you}}$