Question

is there any difference between crawling and gliding ? justify your answer .​

Answer 1

Answer:

Cell migration is a complex process involving many intracellular and extracellular factors, with different cell types adopting sometimes strikingly different morphologies. Modeling realistically behaving cells in tissues is computationally challenging because it implies dealing with multiple levels of complexity. We extend the Cellular Potts Model with an actin-inspired feedback mechanism that allows small stochastic cell rufflings to expand to cell protrusions. This simple phenomenological model produces realistically crawling and deforming amoeboid cells, and gliding half-moon shaped keratocyte-like cells. Both cell types can migrate randomly or follow directional cues. They can squeeze in between other cells in densely populated environments or migrate collectively. The model is computationally light, which allows the study of large, dense and heterogeneous tissues containing cells with realistic shapes and migratory properties.

Author Summary

Cell migration is involved in vital processes like morphogenesis, regeneration and immune system responses, but can also play a central role in pathological processes like metastasization. Computational models have been successfully employed to explain how single cells migrate, and to study how diverse cell-cell interactions contribute to tissue level behavior. However, there are few models that implement realistic cell shapes in multicellular simulations. The method we present here is able to reproduce two different types of motile cells—amoeboid and keratocyte-like cells. Amoeboid cells are highly motile and deform frequently; many cells can act amoeboid in certain circumstances e.g., immune system cells, epithelial cells, individually migrating cancer cells. Keratocytes are (fish) epithelial cells which are famous for their ability to preserve their shape and direction when migrating individually; during wound healing, keratocytes migrate collectively, in sheets, to the site needing reepithelialization. Our method is computationally simple, improves the realism of multicellular simulations and can help assess the tissue level impact of specific cell shapes. For example, it can be employed to study the tissue scanning strategies of leukocytes, the circumstances in which cancer cells adopt amoeboid migration strategies, or the collective migration of keratocytes.

Answer 2

Difference between crawling and gliding:

• Crawling and gliding is the computational models. This models realistically behaving the cells in tissues.
• This very complex models which is being used for cells and genetic studies. The cellular pathways are managed.
• This model produces the realistic crawling and deforming amoeboid cells. The gliding gives half moon shaped keratinocyte cells.
• Hence this model is being used for studying the large, dense and heterogeneous tissues, with proper shape and migration properties.

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