itai-itai disease is associated with
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Itai-itai disease was caused by cadmium poisoning due to mining in Toyama Prefecture. The earliest records of mining for gold in the area date back to 1710. Regular mining for silver started in 1589, and soon thereafter, mining for lead, copper, and zinc began.
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-itai disease is characterised by osteomalaecia with severe bone pain and is associated with renal tubular dysfunction. Itai-itai disease mainly affects women residing in rice farming areas irrigated by the contaminated Jinzu River in Toyama, Japan.
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