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15. The enzymes which are not present in the cytoplasm are
A. Enzymes of Kreb's cycle
B. Enzymes of glycolysis
C. Enzymes of HMP pathway
D. Aminotransferases
Answers
Answer:
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Answer:
Biochemistry, Hexose Monophosphate Pathway
Aziz H, Mohiuddin SS.
Publication Details
Introduction
The hexose monophosphate shunt, also known as the pentose phosphate pathway, is a unique pathway used to create products essential in the body for many reasons. The HMP shunt is an alternative pathway to glycolysis and is used to produce ribose-5-phosphate and nicotinamide adenine dinucleotide phosphate (NADPH). This pathway occurs in the oxidative and non-oxidative phases, each comprising a series of reactions. The HMP shunt also has significance in the medical world, as enzyme or co-factor deficiencies can have potentially fatal implications on the affected patients.
Function
The HMP shunt is parallel to the glycolysis pathway and takes place in the cytoplasm. A 6-carbon sugar, glucose, may enter the glycolytic pathway or enter the alternative HMP shunt depending on the cell’s individual needs at the time. Once the glucose enters the HMP shunt, it undergoes a series of reactions, broken down into the oxidative(irreversible) and non-oxidative phases (reversible). The oxidative phase is responsible for converting the intermediate glucose-6-phosphate to 6-phosphogluconate, using the glucose-6-phosphate dehydrogenase (G6PD) enzyme. The by-product of this reaction is the important molecule NADPH. 6-phosphogluconate then converts into ribulose-5-phosphate, and NADPH gets produced again as a by-product.[1][2][3]