Korundamine a, a novel hiv-inhibitory and antimalarial "hybrid" naphthylisoquinoline alkaloid heterodimer from ancistrocladus korupensis
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A unique heterodimeric naphthylisoquinoline alkaloid, korundamine A (2), comprised of two different monomeric biaryl halves, has been isolated from the Cameroonian tropical liana Ancistrocladus korupensis. Korundamine A is the first “hybrid” dimer found in the Ancistrocladaceae; in vitro, it demonstrated anticytopathic activity against HIV-1 and antimalarial activity against Plasmodium falciparum.
A unique heterodimeric naphthylisoquinoline alkaloid, korundamine A (2), comprised of two different monomeric biaryl halves, has been isolated from the Cameroonian tropical liana Ancistrocladus korupensis.
, korundamine A demonstrated anticytopathic activity against HIV-1 and antimalarial activity against Plasmodium falciparum.
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