Question

Lesch Nyhan disease is an X-linked recessive
disorder that causes neurological damage in human
beings. A survey of 500 mates from a caucasion
population revealed that 20 were effected with this
disorder. What is the frequency of the normal allele
in this population?
(1) 9.6
(2) 0.8
(3) 0.096
(4) 96​

Answer 1

Hi friend here is your answer

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Total mates considered for survey = 500

Individuals affected by the disease = 20

Unaffected individuals = 500-20 = 480

According to the Hardy and Weimberg principle

$p {}^{2} + 2pq \: + q {}^{2} = 1$

Where

p = frequency of the dominant allele

q = Frequency of the recessive allele

Frequency of the recessive allele

$q { }^{2} = 20 \div 500 = 0.04$

$q = 0.2$

We know that

p + q = 1

p = 1- 0.2

p = 0.8

Hence the the frequency of the normal allele is 0.8

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Hope it helps you....................!!

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