Let’s assume that the activation of the DREADD opens one type of ion channel. Given that the resting potential of this neuron is -70 mV (when the DREADD is not activated) and the ionic parameters of the cell below, If we activate this DREADD, how will action potentials be affected?
Ion: Na+ Intracellular (mM): 10 Extracellular (mM):135 Resting permeability: 4
Ion: Cl- Intracellular (mM): 12 Extracellular (mM):125 Resting permeability: 10
Ion: Ca2+ Intracellular (mM): 0.0001 Extracellular (mM):1.8 Resting permeability: 0.01
1. It will be easier to trigger an action potential.
2. It will be more difficult to trigger an action potential.
3. The action potential will have a lower amplitude peak.
4. The action potential will have a higher amplitude peak.
5. Nothing will change.
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