Question

Limitations of Friedel craft acylation

Answer 1

Not given by nh2 oh no2 and highly deactivated ring

3* form alkene and

Many more

Answer 2

Acylation can only be used to give ketones. This is because HCOCl decomposes to CO and HCl under the reaction conditions.

Deactivated benzenes are not reactive to Friedel-Crafts conditions, the benzene needs to be as or more reactive than a mono-halobenzene (see substituent effects)

The Lewis acid catalyst AlCl3 often complexes to aryl amines making them very unreactive.

Amines and alcohols can give competing N or O acylations rather than the require ring acylation.