Limitations of william synthesis
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Limitations of the Reaction
There are few limitations of Williamson Ether Synthesis. Tertiary alkyl halides or sterically hindered primary or secondary alkyl halides tend to undergo E2 elimination in the presence of the alkoxide that in addition to being a nucleophile also act as a base.
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Limitations of the Reaction
There are few limitations of Williamson Ether Synthesis. Tertiary alkyl halides or sterically hindered primary or secondary alkyl halides tend to undergo E2 elimination in the presence of the alkoxide that in addition to being a nucleophile also act as a base.
Explanation:
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