limitations of world health organization (not challenges
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Recognizing the helpful role that experimental challenge studies in healthy adult volunteers have played in the development of certain vaccines, some have advocated a role for such studies with virulent SARS-CoV-2.
However, several factors collectively warrant that special caution must be taken in working with SARS-Cov-2, including:
o the severity of COVID-19 disease, as evidenced by its high case fatality risk in certain sub- populations (elderly, diabetics, hosts with pre-existing pulmonary and cardiac disease);
o severe disease requiring ventilator support and deaths (albeit uncommon) also occurs in young adults, although risk factors for these outcomes in this age group remain uncharacterized; increasing recognition of severe thromboembolic events in young adults