Question

Liquid-liquid phase separation of proteins associated with neurodegenerative diseases.

Answer 1

Recent advances suggest that phase transitions of proteins into liquid or hydrogel states could underlie pathological protein aggregation associated with neurodegenerative disease. In a recent issue of Neuron, Murakami et al. (2015)demonstrate that ALS-associated FUS mutations abrogate the reversibility of condensed liquids and/or hydrogels, leading to neurotoxicity in C. elegans.


i hope help you

Answer 2

Answer:

Besides ALS and FTD, other prominent neurodegenerative diseases have been linked to aberrant phase transitions of proteins. For example, the microtubule-binding protein Tau, which forms neurofibrillary tangles in AD and other tauopathies, also undergoes liquid–liquid phase separation in vitro (9, 67, 153, 157).