Question

List out antibodies (IgG) with its special function.

Answer 1

IgG is generated through isotype switching and makes up a majority of circulating antibody. IgGs are generally higher affinity than the primary IgM antibodies and make up a vast majority of the memory response. IgGs have four major effector functions: 1) neutralization, 2) opsonization, 3) complement fixation, and 4) antibody dependent cell-mediated cytotoxicity (ADCC). Each of the IgG subclasses has slightly different structures that dictate their ability to perform the effector functions previously listed. In past “Biology of Antibodies” blog articles we have examined the development of antibodies ( B Cell development ),
antibody structure , as well as immunoglobulin genetics . With all of that as background, let’s dive a little deeper into the general subject of antibody structure and function, by focusing on IgGs.

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