Question

List out the components of pyruvate dehydrogenase complex.

Answer 1

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Pyruvate dehydrogenase is a multi-enzyme complex that uses three enzymes: E1: Pyruvate dehydrogenase which uses thiamine pyrophosphate (TPP) as its prosthetic group. E2: Dihydrolipoyl transacetylase which uses lipoamide and coenzyme A (also known as coASH) as its prosthetic groups.

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Answer 2

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Initially, pyruvate and thiamine pyrophosphate (TPP or vitamin B1) are bound by pyruvate dehydrogenase subunits. The thiazolium ring of TPP is in a zwitterionic form, and the anionic C2 carbon performs a nucleophilic attack on the C2 (ketone) carbonyl of pyruvate.