List the aminoacids that are modified by kinase in insulin signalling cascade
Answers
Since many of these were identified as cellular homologues of oncogenes, they are represented by three-letter acronyms, such as Crk and Nck. PI3-kinase regulatory subunits. PI3-kinase is a lipid kinase and a key element in the pathway leading to metabolic effects of insulin. Grb2. Crk and Nck
Answer:
The two main pathways of insulin signaling emanating from the insulin receptor-IRS node are the phosphatidylinositol 3-kinase (PI3K, a lipid kinase)/AKT (also known as PKB or protein kinase B) pathway (86,87) and the Raf/Ras/MEK/ MAPK (mitogen activated protein kinase, also known as ERK or extracellular signal regulated kinase) pathway (88). The PI3K pathway is responsible for most metabolic effects of insulin, and is connected exclusively through IRS, while the MAPK pathway emanates from both IRS and Shc and is involved in the regulation of gene expression and, in cooperation with the PI3K pathway, in the control of cell growth ("mitogenesis") and differentiation (82).
Explanation for figure attached below;
The canonical insulin receptor signal transduction network. The two major canonical insulin receptor signaling cascades (PI3K and ERK) are shown. The critical nodes (IR/IRS, PI3K, AKT) are boxed. Crosstalk from IGF-I receptor, cytokine receptors and TNFα is indicated. Negative regulation by PTP1B and PTEN is shown. See text and reference 83 for detailed explanation. From reference 82, used with permission.
