liver develops from...
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Explanation:
Early liver development starts with formation and patterning of the endoderm. The ventral endoderm differentiates into thyroid, lung, liver, and pancreas and the dorsal endoderm differentiates into pancreas and intestines (Fig. 1). The events leading to differentiation of the ventral endoderm to hepatoblasts, then the liver bud, and eventually a formed liver are due to liver specific transcriptional programs and external signaling events originating from the cardiac mesoderm. The forkhead box A (FoxA) genes are highly regulated and control gut development throughout the animal kingdom. Fox A proteins regulate almost all liver-specific genes as well as a number of genes specific to the lung and pancreas. These proteins have a 110-amino-acid DNA-binding domain and regulate gene transcription. In addition to the FoxA proteins, a subclass of the GATA zinc finger transcription factors is important for liver-specific gene expression (e.g., albumin).
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