Question

Loss of major molecular response as a trigger for restarting tyrosine kinase inhibitor therapy in patients with chronic-phase chronic myelogenous leukemia who have stopped imatinib after durable undetectable disease

Answer 1

Explanation:

(i) Raisins in beaker A with plain water will get swollen due to endosmosis while raisins in beaker B with concentrated sugar solution will get shrink due to exosmosis.

(ii) Plain water is hypotonic while concentrated sugar solution is hypertonic.

Answer 2

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Median to time to second CMR was estimated as 7.3 months in re-treated patients. Conclusion: Loss of MMR is a practical and safe criterion for restarting therapy in patients with CML with prolonged CMR.

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