Question

Lysosomal targeting of proteins involves recognition of

Answer 1

Mammals too, seem to have conserved in part the more primordial sorting mechanisms, which depend only on protein signals. Ly- sosomal proteins which are synthesized and transported as integral membrane proteins are sorted to lysosomes by a mechanism that depends on a protein signal in their cy- toplasmic tail

Answer 2

Lysosomal targeting of protein involves recognition of mannose 6 phosphate.

As, the cis side of golgi apparatus sends protein with a specific particle of mannose which further gets modified to mannose-6-phosphate and then from trans side m6p +protein enters into early endosome. At the same time proton pump activates (addition of H+ ions) and protein + m6p disintigrates and proteins goes for further modification. And m6p recycled back to golgi apparatus