Question

Lysosomal targeting of proteins involves recognition of (a) n-terminal signal peptide alone (b) mannose phosphorylated at 6th carbon in n-linked oligosaccharide (c) kdel sequence at the c-terminus (d) dilysine motifs in the internal sequence of the protein

Answer 1

Lysosomal targeting of proteins involves recognition of (a) n-terminal signal peptide alone (b) mannose phosphorylated at 6th carbon in n-linked oligosaccharide (c) kdel sequence at the c-terminus (d) dilysine motifs in the internal sequence of the protein

Answer: b) mannose phosphorylated at 6th carbon in n-linked oligosaccharide

Reason for the answer is:

Lysosomes are basically composed of soluble and transmembrane proteins that are targeted to lysosomes in a signal-dependent manner. The majority soluble acid hydrolases are modified with mannose 6- phosphate (M6P) residues which allows their recognition by M6P receptors in the Golgi complex and ensuing transport to the endosomal/lysosomal system.

Answer 2

"The answer to this question is the option no “B.” Lysosomal targeting of proteins involves recognition

Of mannose phosphorylated at 6th carbon in n-linked oligosaccharide. There are the different structure of the sugar relation to form high energy bonds and the carbohydrate bonds.

They are a major part of the plasma – membrane containing protein and part of the carbohydrate chain.

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