lysosome digest damaged cells
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Yes. Lysosomes digest the damaged cells in our body but sometimes it also digest the healthy cells that's why it is also called Suicidal bag.
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lysosomes
Wednesday 24 September 2003
Definition: Lysosomes are dynamic organelles that receive and degrade macromolecules from the secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways.
Lysosomes are organelles that contain digestive enzymes (acid hydrolases). They digest excess or worn out organelles, food particles, and engulfedviruses or bacteria. The membrane surrounding a lysosome prevents the digestive enzymes inside from destroying the cell. Lysosomes fuse with vacuoles and dispense their enzymes into the vacuoles, digesting their contents. They are built in the Golgi apparatus.
The name lysosome derives from the Greek words lysis, which means dissolution or destruction, and soma, which means body. They are frequently nicknamed "suicide-bags" or "suicide-sacs" by cell biologists due to their role in autolysis. Lysosomes were discovered by the Belgian cytologist Christian de Duve in 1949.
The word "lysosome" is Latin for "kill body." Lysosomes are organelles produced by the Golgi apparatus that contain powerful protein digesting enzymes. Lysosomes are responsible for the breakdown and absorption of materials taken in by the cell.
Lysosomes are key components of the "intracellular digestive tract." They contain a battery of hydrolytic enzymes, which have two special properties. First, they can function in the acid milieu of the lysosomes. Second, these enzymes constitute a special category of secretory proteins that, in contrast to most others, are destined for secretionnot into the extracellular fluids but into an intracellular organelle. This latter characteristic requires special processing within the Golgi apparatus, which is reviewed briefly.
Function
The lysosomes are used for the digestion of macromolecules from phagocytosis (ingestion of other dying cells or larger extracellular material), endocytosis (where receptor proteins are recycled from the cell surface), and autophagy (where old or unneeded organelles or proteins, or microbes which have invaded the cytoplasm are delivered to the lysosome). Autophagy may also lead to autophagic cell death, a form of programmed self-destruction, or autolysis, of the cell, which means that the cell is digesting itself.
Other functions include digesting foreign bacteria (or other forms of waste) that invade a cell and helping repair damage to the plasma membrane by serving as a membrane patch, sealing the wound. Lysosomes also do much of the cellular digestion required to digest tails of tadpoles and to remove the web from the fingers of a 3-6 month old fetus. This process of programmed cell death is called apoptosis.
Fusion
Live-cell imaging has shown that fusion with lysosomes occurs by both transient and full fusion events, and yeast genetics and mammalian cell-free systems have identified much of the protein machinery that coordinates these fusion events.
Infectious diseases
Many pathogens that hijack the endocytic pathways to enter cells have evolved mechanisms to avoid being degraded by the lysosome. However, the function of lysosomes is not restricted to protein degradation: they also fuse with the plasma membrane during cell injury, as well as having more specialized secretory functions in some cell types.
Acidic environment
At pH 4.8, the interior of the lysosomes is more acidic than the cytosol (pH 7.2). The lysosome’s single membrane stabilizes the low pH by pumping in protons (H+) from the cytosol via proton pumps and chloride ion channels. The membrane also protects the cytosol, and therefore the rest of the cell, from the degradative enzymes within the lysosome. For this reason, should a lysosome’s acid hydrolases leak into the cytosol, their potential to damage the cell will be reduced, because they will not be at their optimum p
Wednesday 24 September 2003
Definition: Lysosomes are dynamic organelles that receive and degrade macromolecules from the secretory, endocytic, autophagic and phagocytic membrane-trafficking pathways.
Lysosomes are organelles that contain digestive enzymes (acid hydrolases). They digest excess or worn out organelles, food particles, and engulfedviruses or bacteria. The membrane surrounding a lysosome prevents the digestive enzymes inside from destroying the cell. Lysosomes fuse with vacuoles and dispense their enzymes into the vacuoles, digesting their contents. They are built in the Golgi apparatus.
The name lysosome derives from the Greek words lysis, which means dissolution or destruction, and soma, which means body. They are frequently nicknamed "suicide-bags" or "suicide-sacs" by cell biologists due to their role in autolysis. Lysosomes were discovered by the Belgian cytologist Christian de Duve in 1949.
The word "lysosome" is Latin for "kill body." Lysosomes are organelles produced by the Golgi apparatus that contain powerful protein digesting enzymes. Lysosomes are responsible for the breakdown and absorption of materials taken in by the cell.
Lysosomes are key components of the "intracellular digestive tract." They contain a battery of hydrolytic enzymes, which have two special properties. First, they can function in the acid milieu of the lysosomes. Second, these enzymes constitute a special category of secretory proteins that, in contrast to most others, are destined for secretionnot into the extracellular fluids but into an intracellular organelle. This latter characteristic requires special processing within the Golgi apparatus, which is reviewed briefly.
Function
The lysosomes are used for the digestion of macromolecules from phagocytosis (ingestion of other dying cells or larger extracellular material), endocytosis (where receptor proteins are recycled from the cell surface), and autophagy (where old or unneeded organelles or proteins, or microbes which have invaded the cytoplasm are delivered to the lysosome). Autophagy may also lead to autophagic cell death, a form of programmed self-destruction, or autolysis, of the cell, which means that the cell is digesting itself.
Other functions include digesting foreign bacteria (or other forms of waste) that invade a cell and helping repair damage to the plasma membrane by serving as a membrane patch, sealing the wound. Lysosomes also do much of the cellular digestion required to digest tails of tadpoles and to remove the web from the fingers of a 3-6 month old fetus. This process of programmed cell death is called apoptosis.
Fusion
Live-cell imaging has shown that fusion with lysosomes occurs by both transient and full fusion events, and yeast genetics and mammalian cell-free systems have identified much of the protein machinery that coordinates these fusion events.
Infectious diseases
Many pathogens that hijack the endocytic pathways to enter cells have evolved mechanisms to avoid being degraded by the lysosome. However, the function of lysosomes is not restricted to protein degradation: they also fuse with the plasma membrane during cell injury, as well as having more specialized secretory functions in some cell types.
Acidic environment
At pH 4.8, the interior of the lysosomes is more acidic than the cytosol (pH 7.2). The lysosome’s single membrane stabilizes the low pH by pumping in protons (H+) from the cytosol via proton pumps and chloride ion channels. The membrane also protects the cytosol, and therefore the rest of the cell, from the degradative enzymes within the lysosome. For this reason, should a lysosome’s acid hydrolases leak into the cytosol, their potential to damage the cell will be reduced, because they will not be at their optimum p
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