Main stimulus for the process of erythropoesis is- Decrease in number of RBC Decrease in concentration of Hb Reduced 0, supply to tissues. Decrease in erythropoetin hormone
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The primary stimulus for increased EPO synthesis is tissue hypoxia caused by decreased blood O2 availability. This hypoxia signal is received primarily in the kidney, which responds by increasing production and secretion of EPO
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Epo secretion is stimulated by hypoxia, which is detected by an oxygen sensor located in the kidney. This oxygen sensor has been recently shown to be an heme protein
The hormone erythropoietin (Epo) maintains red blood cell mass by promoting the survival, proliferation and differentiation of erythrocytic progenitors. Circulating Epo originates mainly from fibroblasts in the renal cortex. Epo production is controlled at the transcriptional level.
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