Many of the clotting factors and proteins are made in which organ?
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The main organ is LIVER.
Liver cells or hepatocytes are involved in the synthesis of most blood coagulation factors. Ex - fibrinogen, prothrombin, factor V, VII, IX, X, XI, XII, protein C and S, and antithrombin. Moreover liver sinusoidal endothelial cells produce factor VIII and von Willebrand factor.
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