Question

mark the correct mechanism of action
Amphotericin Bi
fon
A - Inhibition of DNA synthesis
B- Alteration of cell
membrane permeability

c- Inhibition of fungal protein synthesis
D- Inhibition of cell wall synthesis​

Answer 1

Amphotericin B binds with ergosterol, a component of fungal cell membranes, forming pores that cause rapid leakage of monovalent ions (K+, Na+, H+ and Cl−) and subsequent fungal cell death. This is amphotericin B's primary effect as an antifungal agent.