Question

Mechanism of action of cell surface receptors

Answer 1

MechanismEdit

Two models have been proposed to explain transmembrane receptors' mechanism of action.

Dimerization: The dimerization model suggests that prior to ligand binding, receptors exist in a monomeric form. When agonist binding occurs, the monomers combine to form an active dimer.

Rotation: Ligand binding to the extracellular part of the receptor induces a rotation (conformational change) of part of the receptor's transmembrane helices. The rotation alters which parts of the receptor are exposed on the intracellular side of the membrane, altering how the receptor can interact with other proteins within the cell.


plzzz mark me as brainliest...