Question

Mechanism of action of pregabalin in pan management

Answer 1

Pregabalin: its pharmacology and use in pain management

Noor M Gajraj

Anesthesia & Analgesia 105 (6), 1805-1815, 2007

Pregabalin is a new synthetic molecule and a structural derivative of the inhibitory neurotransmitter-aminobutyric acid. It is an 2-(2-) ligand that has analgesic, anticonvulsant, anxiolytic, and sleep-modulating activities. Pregabalin binds potently to the 2-subunit of calcium channels, resulting in a reduction in the release of several neurotransmitters, including glutamate, noradrenaline, serotonin, dopamine, and substance P. In this review, I will discuss the pharmacology of pregabalin and available efficacy studies in pain management. This review will …

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Recent advances in postoperative pain management

Nalini Vadivelu, Sukanya Mitra, Deepak Narayan

The Yale journal of biology and medicine 83 (1), 11, 2010

Good pain control after surgery is important to prevent negative outcomes such as tachycardia, hypertension, myocardial ischemia, decrease in alveolar ventilation, and poor wound healing. Exacerbations of acute pain can lead to neural sensitization and release of mediators both peripherally and centrally. Clinical wind up occurs from the processes of N-Methyl D-Aspartate (NMDA) activation, wind up central sensitization, long-term potentiation of pain (LTP), and transcription-dependent sensitization. Advances in the knowledge of molecular mechanisms have led to the development of multimodal analgesia and new pharmaceutical products to treat postoperative pain. The new pharmacological products to treat postoperative pain include extended-release epidural morphine and analgesic adjuvants such as capsaicin, ketamine, gabapentin, pregabalin dexmetomidine, and tapentadol. Newer postoperative patient-controlled analgesia (PCA) in modes such as intranasal, regional, transdermal, and pulmonary presents another interesting avenue of development.