Question

Mechanism of hoffmann bromamide degradation reaction

Answer 1

The answer is given below

Answer 2

ANSWER:

✔Hoffmann developed a method for preparation of primary amines by treating an amide with bromine in an aqueous or ethanolic solution of sodium hydroxide.

✔In this degradation reaction, migration of an alkyl or aryl group takes place from carbonyl carbon of the amide to the nitrogen atom.

✔The amide so formed contains one carbon less than that present in the amide.

⭐Reaction ----

RCONH2 + Br2 +4NaOH ➡RNH2 + Na2CO3 + 2NaBr + 2H2O