Question

Mechanism to response of T-lymphocyte to antigen

Answer 1

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Mechanism of response of T-lymphocytes to antigens:

On coming in contact with an antigen,

a T-lymphocyte forms clones of T-cells which are similar but they perform different functions.

The clone has four types of T-lymphocytes:

i. Helper T-cells: Sensitized helper T-cells

produce lymphokines for performing several types of functions like proliferation of other T-cells, stimulation of B-lymphocytes, macrophages, etc.

ii. Killer T-cells or Cytotoxic T-cells: They

directly attack and destroy invading

microbes, infected body cells and cancer

cells. Killer T-cells bind to infected cell

and secrete perforins. Then perforins form a hole in infected cell. It also releases substances that kill the cell, hence the name cytotoxic T-cell.

iii. Suppressor T-cells: These cells suppress entire immune system against attack on the own body cells.

iv. Memory T-cells: These are previously

sensitized cells which retain the

sensitization memory for long time in the

future.