Membrane protein whose removal does not require crude method of treatment like detergent
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The hydrophobic portion of a detergent allows the molecule to partition into the apolar lipid bilayer during the solubilization of membrane proteins . It also masks the hydrophobic portions of the membrane proteins once they have been solubilized and, thus, prevents protein aggregation .
The amino acid chain of transmembrane proteins, which often are transmembrane receptors, passes through a membrane one or several times. They are inserted into the membrane by translocation, until the process is interrupted by a stop-transfer sequence, also called a membrane anchor or signal-anchor sequence.
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