Membrane proteins whise removal does not require crude method of treatment like detegents are
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Denaturing detergents such as SDS bind to both membrane (hydrophobic) and non-membrane (water-soluble, hydrophilic) proteins at concentrations below the CMC (i.e., as monomers). ... Detergent monomers solubilize membrane proteins by partitioning into the membrane bilayer.
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