Mention the chemical change that proinsulin undergo to be able to act as mature insulin
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The proinsulin is cleaved to remove extra stretch called the C-peptide to form mature insulin having only A-chain and B-chain joined by disulphide bond
Both C-peptide and mature insulin are biologically active. Cell components and proteins in this image are not to scale. Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans, specialized regions of the pancreas. In humans, proinsulin is encoded by the INS gene.
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The proinsulin is cleaved to remove extra stretch called the C-peptide to form mature insulin having only A-chain and B-chain joined by disulphide bond
Both C-peptide and mature insulin are biologically active. Cell components and proteins in this image are not to scale. Proinsulin is the prohormone precursor to insulin made in the beta cells of the islets of Langerhans, specialized regions of the pancreas. In humans, proinsulin is encoded by the INS gene.
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