Mention two sex linked genetic disorders and their symptoms
Answers
Haemophilia: Haemophilia is an inherited bleeding disorder where the blood doesn't clot properly. It is caused when blood does not have enough clotting factor. A clotting factor is a protein in blood that controls bleeding. There are two types of haemophilia. Both have the same symptoms.
Sickle cell anemia: Sickle cell anemia (sickle cell disease) is a disorder of the blood caused by an inherited abnormal hemoglobin (the oxygen-carrying protein within the red blood cells). The abnormal hemoglobin causes distorted (sickled appearing under a microscope) red blood cells.
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Main X-linked recessive disorders are:-
Duchenne's muscular dystrophy:- In this disease, dystrophin protein is absent in muscles. This protein provide tensile strength to sarcolemma and prevent tearing during contraction. This protein also helps in conduction of Ca++ ion. Because of the deficiency of dystrophin protein, muscles contraction do not occur properly.
G-6-Phosphate Dehydrogenase deficiency syndrome:- It is a enzyme which is present in RBC. This enzyme stabilize the membrane of R.B.C. Deficiency of this enzyme is the main cause rupture of R.B.C, when it comes in contact with sulfa drug, chloroquine, Fava bean (Favism), legumes.