Biology, asked by roshni1201, 1 year ago

Microbiota from lean twins protect against obesity induced by microbiota from obese twins, when transferred to mice (ridaura et al., 2013

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Answered by Anonymous
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The role of specific gut microbes in shaping body composition remains unclear. We transplanted fecal microbiota from adult female twin pairs discordant for obesity into germ-free mice fed low-fat mouse chow, as well as diets representing different levels of saturated fat and fruit and vegetable consumption typical of the USA. Increased total body and fat mass, as well as obesity-associated metabolic phenotypes were transmissible with uncultured fecal communities, and with their corresponding fecal bacterial culture collections. Co-housing mice harboring an obese twin’s microbiota (Ob) with mice containing the lean co-twin’s microbiota (Ln) prevented the development of increased body mass and obesity-associated metabolic phenotypes in Ob cagemates. Rescue correlated with invasion of specific members of Bacteroidetes from the Ln microbiota into Ob microbiota, and was diet-dependent. These findings reveal transmissible, rapid and modifiable effects of diet-by-microbiota interactions.

Microbial community configurations vary substantially between unrelated individuals (1–9), creating a challenge in designing surveys of sufficient power to determine whether observed differences between disease-associated and healthy communities differ significantly from normal interpersonal variation. This challenge is especially great if, for a given disease state, there are many associated states of the microbial species (microbiota) or microbial gene repertoire (microbiome), each shared by relatively few individuals. Microbiota configurations are influenced by early environmental exposures and are generally more similar among family members (2, 7, 10, 11).

Answered by Anonymous
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Answer:

Co-housing mice harboring an obese twin's microbiota (Ob) with mice ... mice protects against obesity and improves insulin sensitivity (42).

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