Microsomal triglyceride transfer protein and its role in apob-lipoprotein assembly
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Apolipoprotein B (apoB) and microsomal triglyceride transfer protein (MTP) are necessary for lipoprotein assembly. ApoB consists of five structural domains, βα1-β1-α2-β2-α3. We propose that MTP contains three structural motifs (N-terminal β-barrel, central α-helix, and C-terminal lipid cavity) and three functional domains (lipid transfer, membrane associating, and apoB binding). MTP's lipid transfer activity is required for the assembly of lipoproteins. This activity renders nascent apoB secretion-competent and may be involved in the import of triglycerides into the lumen of endoplasmic reticulum.
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Answer:
The microsomal triglyceride transfer protein (MTP) is a lipid transfer protein involved in the assembly and secretion of apolipoprotein-B-containing lipoproteins (Hooper et al., 2015); it transfers neutral lipids (triglycerides and cholesteryl esters) from the endoplasmic reticulum membrane to the nascent apoB (Hooper ...