Question

Mithochondrial complex i gene variant associated with early age of onset in sca2,

Answer 1

A common mitochondrial complex I gene polymorphism (10398G) is reported to be inversely associated with the risk of Parkinson disease. We hypothesized that this variant might have a protective effect on the central nervous system and therefore might delay the onset of symptoms in spinocerebellar ataxia type 2 (SCA2).

OBJECTIVE: To assess the association of the 10398G polymorphism with age at onset in Cuban patients with SCA2.