Molecular and cellular pathophysiology of heart failure
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The molecular and cellular pathophysiology of heart failure. Author information: ... Cellular changes in heart failure include myocyte hypertrophy, abnormalities in calcium homeostasis, excitation-contraction coupling, cross-bridge cycling, and changes in the cytoskeletal architecture.
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pathophysiology of heart failure
the onset of heart failure may be acute or insidoius. it is often assosciated with systolic and distolic over loading and and with myocardial weakness. as the physiologic stress on the hear muscles reaches a critical level,the contractility of the muscles is reduced and cardiac output declines,but the venous input of the ventricles of heart is remains sameor become sincreased which is responsible for cardiac overload.
when cardiac output is decreased ;the body undergoes alteration to compensate for the failure.
2 types of compensatory mechanism
- systemic compensatory mechanism
- renin angiotensin aldosterone system
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