Question

Molecules involved in myofibroblast activation in kidney

Answer 1

a number of molecules using different transforming growth factor (TGF)-β1-induced signaling pathways are involved that activate a wide variety of cells leading to a terminal event known as “scarring or fibrosis” in various organ systems. Likewise, renal fibrosis is an inevitable consequence of various types of progressive chronic kidney diseases (CKD), and it is characterized by continued exacerbation of glomerulosclerosis, tubular atrophy, and interstitial fibrosis, which leads to irreversible kidney scarring. In the clinical setting, CKD patients with recalcitrant renal fibrosis manifest with progressive renal function loss, and they ultimately develop end-stage renal disease (ESRD), which requires renal replacement therapy (10)..

i hope help you

Answer 2

Answer:

Whether such epigenetic changes are involved in fibroblast activation associated with ... While molecular evidence for such thinking is lacking in the kidney, an elegant study that used ..