Monodistearoylphosphatidylethanolamine-hyaluronic acid functionalization of single-walled carbon nanotubes for targeting intracellular drug delivery to overcome multidrug resistance of cancer cells
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Here we synthesized a multifunctional modifier of single-walled carbon nanotubes (SWCNTs), distearoylphosphatidylethanolamine-hyaluronic acid (DSPE-HA) conjugate with a single coupling point, to simultaneously disperse SWCNTs, improve the biocompatibility of SWCNTs and target SWCNTs to CD44-overexpressing MDR cancer ...
For the failure of chemotherapy, cancer's multidrug resistance (MDR) is a major cause. Here we combine single-walled carbon nanotube (SWCNT), distierial phosphatidethhenolanamine-hyaluronic acid (DSPE-HA) with a single coupling point, spread to SWCNT, improve the biocompattability of SWCNT and target CD44-overxpressing To synthesize a multi-dimensional modifier. MDR cancer cells to improve intracellular drug delivery and to overcome MDR. Taking Aspubicin (EPI) as a Model Drug and DSPE-HA implemented SWCNT as a career, a drug delivery system EPI-SWCNTS-DSPE-HA was constructed. Intracellular ePi delivery efficiency of EPI-SWCNT-DSPE-HA and MDR-reverse effects were investigated in drug resistant A-549 / taxol cells and tumor spheroid. The results show that EPI-SWCNTS-DSPE-H has significantly increased intracellular delivery and EPI retention by preventing the flow of medication except the mechanism of CD44 receptor-mediated endocytosis and p-glycoprotein (P-GP) pump. . Efi-SWCNTS-DSPE-HA treatment effectively passed the MDR of cancer cells and tumor spheroid and vaccine SWCNT- DSPE-HA did not have any significant cytotoxicity in which it was shown that SWCNTS-DSPE-HD MDR cancers Is a promising carrier for drug delivery