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In Nagai synthesis, starting materialj for the synthesis of ephedrine is
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Abstract
Ephedra compounds are well known due to their biological activity. They have been widely used in asymmetric synthesis during the last decades. Recently, we have prepared reviews about the synthesis of acyclic and heterocyclic ephedra derivative compounds reported in the literature. In this chapter, the synthetic methodology to access acyclic and heterocyclic compounds derived from ephedra alkaloids and its structural analysis are discussed, included those due to the substitution of the hydroxy group by chlorine, sulfur, selenium, or nitrogen atoms. Biological activity analysis of some synthesized
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