Mutations in the genes encoding dll1 (a notch ligand), notch1 (a notch receptor), rbpj (rbpj mouse genome informatics; a notch transcriptiona (effector), hes1, hes3 or hes5 (rbpjk-induced transcription factors) all lead to the depletion of radial glia stem cells and to precocious neuronal differentiation in the mouse embryo
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