Question

Mutations in the genes that code for proteins in this pathway have been linked to various types ofcancer (i.e., RAS: pancreatic, BRAF: colorectal, MEK: melanoma, EGFR: lung). If you were developing anew cancer drug, what would be an appropriate target protein for the new drug therapy? Justify youranswer.

Answer 1

Answer:

Various gene mutations result in altered proteins that cause various types of cancers. Each cancer is caused by a different mutation in a gene that encodes different and modified proteins. The development of new drugs against all types of cancers should aim at a common step in all pathways. This can be achieved by developing anti-angiogenesis therapy.

Anticancer therapeutic research is a targeted therapy aimed at inhibiting several types of cells that participate in angiogenesis and multiple signaling channels for intercommunication within tumors. Blocking angiogenesis and inhibiting angiogenesis products is a highly effective strategy for cancer treatment.