Question

Mutations in the genome of E. coli are introduced at a rate of 1/10° bp per generation. If a
scientist starts with a colony of 10 cells having 1000 bp DNA, the number of mutant cells observed after two doubling times will be:

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Answer 1

The average mutation rate was estimated to be approximately 2.5 x 10(-8) mutations per nucleotide site or 175 mutations per diploid genome per generation.

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