Question

My wife is good___English. correct preposition​

Answer 1

Answer:

My wife is good in English.

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Answer 2

Answer:

Good at and good in refer to competence in an activity, whereas good with refers to competence at using something. We can expand the examples you provide to demonstrate the difference: Good at: "She is good at the activity of speaking English." Good with: "She is good with the English language."