Question

Name any two disorders of the musculo–skeletal system which are hereditary.

Answer 1

Achondroplasia and osteogenesis impercta are two genetic disorders of musculoskeletal system.

Explanation:

The two genetic disorders that affect the musculoskeletal system are- i) Achondroplasia – It is a disorder that occurs when the growth of fibroblast initiates the change in DNA causing abnormality in formation of cartilage.

The symptom includes- short- height; ii) Osteogenesis imperfecta- It occurs when the deficiency of proteins connects with the CRTAP, PPIB and other collagens by the mutation process in encoding gene.In this disorder, bones become fragile and fractures occur.

Answer 2

Dear Student,

● Answer -

Hereditary disorders of musculo–skeletal system -

1. Osteogenesis imperfecta
2. Osteoporosis
3. Achondroplasia
4. Hurler syndrome
5. Marfan syndrome
6. Connective tissue disorders

# Osteogenesis imperfecta -

• It was also known as brittle bone disease / friagilitas ossium.
• It is characterized by fragile bones and break easily.
• Defect in gene responsible for collagen synthesis.
• There is no collagen to strengthen bones.

Thanks dear. Hope this helps you...