Name any two fungi causing powdery mildew disease?
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Fungi rarely cause disease in healthy immunocompetent hosts. Disease results when fungi accidentally penetrate host barriers or when immunologic defects or other debilitating conditions exist that favor fungal entry and growth.
Adaptation and Propagation
Fungi often develop both virulence mechanisms (e.g., capsule and ability to grow at 37oC) and morphologic forms (e.g., yeasts, hyphae, spherules, and sclerotic bodies) that facilitate their multiplication within the host.
Dissemination
Dissemination of fungi in the body indicates a breach or deficiency of host defenses (e.g., endocrinopathies and immune disorders).
Host Factors
Healthy, immunologically-competent individuals have a high degree of innate resistance to fungi. Resistance to fungi is based primarily upon cutaneous and mucosal physical barriers. Severity of disease depends on factors such as inoculum, magnitude of tissue destruction, ability of fungus to multiply in the tissue, and the immune status of the host.
Fungal Factors
Enzymes such as keratinase, the presence of capsule in Cryptococcus neoformans, the ability to grow at 37°C, dimorphism, and other as yet undefined factors contribute to fungal pathogenesis which involves a complex interplay of many fungal and host factors.
Adaptation and Propagation
Fungi often develop both virulence mechanisms (e.g., capsule and ability to grow at 37oC) and morphologic forms (e.g., yeasts, hyphae, spherules, and sclerotic bodies) that facilitate their multiplication within the host.
Dissemination
Dissemination of fungi in the body indicates a breach or deficiency of host defenses (e.g., endocrinopathies and immune disorders).
Host Factors
Healthy, immunologically-competent individuals have a high degree of innate resistance to fungi. Resistance to fungi is based primarily upon cutaneous and mucosal physical barriers. Severity of disease depends on factors such as inoculum, magnitude of tissue destruction, ability of fungus to multiply in the tissue, and the immune status of the host.
Fungal Factors
Enzymes such as keratinase, the presence of capsule in Cryptococcus neoformans, the ability to grow at 37°C, dimorphism, and other as yet undefined factors contribute to fungal pathogenesis which involves a complex interplay of many fungal and host factors.
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