Biology, asked by dada4136, 7 months ago

Name
one
evolutionary conservative
molecure​

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Answered by Typhoone
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An important question in evolutionary biology is how organisms regulate biological processes reproducibly in the midst of genetic and environmental changes (Wagner 2007). For faithful execution of gross cellular processes, such as development, cell cycle, and reproduction, gene expression must be regulated properly at the molecular level. How stable gene regulation is mechanistically achieved is an ongoing area of research in evolution (Masel and Siegal 2009).

Eukaryotic genomes are organized into chromatins, in which DNA sequences wrap around histone octamers to form nucleosomes. Posttranslational modification of histones (histone modification) at different regulatory regions can activate or repress gene expression (Wang et al. 2008; Heintzman et al. 2009; Ernst et al. 2011; Negre et al. 2011). Their importance in eukaryotic gene expression is supported by the fact that misregulation of chromatins can result in lower fitness of the organism, developmental defects, or diseases (Hendrich and Bickmore 2001). Histone modifications can be influenced by many factors, such as DNA mutations, cellular environmental variations, and external environmental variations (Bernstein et al. 2005; Ku et al. 2008; Mikkelsen et al. 2010; Cain et al. 2011; Ernst et al. 2011; Negre et al. 2011; Wang et al. 2011). Because stabilizing mechanisms have a genetic basis and can evolve (Waddington 1942), we wondered if eukaryotic genomes have mechanisms to stably maintain histone modifications.

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